Jaewon Min, PhD
- Assistant Professor of Pathology and Cell Biology (in the Institute for Cancer Genetics)
Overview
Academic Appointments
- Assistant Professor of Pathology and Cell Biology (in the Institute for Cancer Genetics)
Gender
- Male
Credentials & Experience
Honors & Awards
- 2003 – 2007 National Science & Technology Scholarship
- 2009 – 2011 Hi-Seoul Science Fellowship
- 2014 – 2016 CPRIT Postdoctoral Cancer Intervention and Prevention Discovery Training Program
- 2017 – 2019 NIH/NCI T32 Cancer Research Training Program
- 2021 – 2024 NIH/NCI K22 Career Transition Award
- 2024 – NIH/NIGMS R35 Maximizing Investigators' Research Award
Research
My overall goal as a cancer cell biologist is to decipher the cellular and molecular phenomena that occur in cancer to facilitate the development of new ways to prevent, diagnose and treat cancer. I have been studying the telomere maintenance mechanism that is essential for the initiation and progression of cancer. I have focused on the alternative lengthening of telomeres (ALT) pathway, a telomerase-independent telomere maintenance mechanism that frequently occurs in mesenchymal origin human cancers (i.e., sarcomas, endocrine tumors, and soft tissue cancers- brain tumors; glioblastoma and in a subset of pediatric cancers, neuroblastoma).
The Min laboratory (a.k.a., Telomere Biology Lab at Columbia) will identify how cancer cells acquire telomere maintenance mechanisms independent of telomerase during tumorigenesis and how to target such telomere maintenance mechanisms as an anti-cancer strategy.
Selected Publications
- Wondisford, A.R., Lee, J., Lu, R., Schuller, M., Groslambert, J., Bhargava, R., Schamus-Haynes, S., Cespedes, L.C., Opresko, P.L., Pickett, H.A., Min, J., Ahel, I., O'Sullivan, R.J. (2024) Deregulated DNA ADP-ribosylation impairs telomere replication. Nat Struct Mol Biol. 2024 May;31(5):791-800. Epub 2024 May 7. PubMed PMID: PMID: 38714889
- Lee, J., Lee, J., Sohn, E.J., Taglialatela, A., O'Sullivan, R.J., Ciccia, A., and Min, J. (2024) Extrachromosomal telomere DNA derived from excessive strand displacements. Proc Natl Acad Sci USA. 2024 May 7;121(19):e2318438121. PubMed PMID: 38696464
- Min, J., and Gautier, J. (2023) Chromatin compartments at DNA double-stranded breaks. Cell Res. doi: 10.1038/s41422-023-00912-1. PubMed PMID: 38097773
- Min, J., Zhao J., Zagelbaum J., Lee J., Takahashi S., Cummings P., Schooley A., Dekker J., Gottesman M., Rabadan R., and Gautier J. (2023) Mechanisms of insertions at a DNA double-strand break. Molecular Cell. Jul 20; PubMed PMID: 37402370
*Featured ariticle in Molecular Cell - Sohn, E.J., Goralsky, J.A., Shay, J.W., and Min, J. (2023) The Molecular Mechanisms and Therapeutic Prospects of Alternative Lengthening of Telomeres (ALT). Cancers (Basel) 15(7):1945 PubMed PMID: 37046606
- Min, J., and Shay, J.W. (2019) Telomere clustering drives ALT. Aging (Albany NY). 11:8046-9047 (Editorial article) PubMed PMID: 31612868
- Min, J., Wright, W.E. and Shay, J.W. (2019) Clustered Telomeres in Phase-Separated Nuclear Condensates Engage Mitotic DNA Synthesis through BLM and RAD52. Genes & Development. Jul 1;33(13-14):814-827. PubMed PMID: 31171703
*Cover image in Genes & Development July 1, 2019
**Spotlighted by Flynn, R.L. and Heaphy C.M. (2019) Surviving telomere attrition with the MiDAS touch. Trends Genet. PubMed PMID: 31526614 - Min, J., Wright, W.E. and Shay, J.W. (2017) Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Mol. Cell. Biol. 26;37(20) PubMed PMID: 28760773
- Min, J., Wright, W.E. and Shay, J.W. (2017) Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Res. 10.1093/nar/gkw1295. PubMed PMID: 28082393
For a complete list of publications, please visit:
https://scholar.google.com/citations?hl=en&user=tu-gf0UAAAAJ&view_op=list_works&sortby=pubdate