Jianwen Que, MD, PhD

  • Professor of Medicine, Department of Medicine

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Overview

Jianwen Que, MD, PhD is a Professor of Medicine at Columbia University Medical Center (CUMC). His research is focused on the role of stem/progenitor cells in homeostasis and disease pathogenesis in gastrointestinal organs including esophagus, stomach etc. He is the Faculty Director of the Genetically Modified Mouse Models Shared Resource (GMMSR) at the Herbert Irving Comprehensive Cancer Center (HICCC) and Director of the Columbia Center for Human Development at Columbia University. Dr. Que is a member of several national organizations and societies, including the American Gastroenterological Association and The American Society for Clinical Investigation (ASCI), and serves as Editor-in-Chief of the Journal of Respiratory Biology and Translational Medicine. He received his PhD from the National University of Singapore in the Department of Surgery and his MD from Peking University.

Academic Appointments

  • Professor of Medicine, Department of Medicine

Administrative Titles

  • Director, Columbia Center for Human Development
  • Faculty Director, Genetically Modified Mouse Models Shared Resource, HICCC

Credentials & Experience

Education & Training

  • MD, Health Science Center, Peking University, Beijing, China
  • PhD, Department of Surgery, National University of Singapore
  • Postdoctoral Fellowship, Duke University

Committees, Societies, Councils

  • Member, The LungMAP2 external advisory committee (NIH)
  • Member, International Society for Diseases of the Esophagus
  • Member, American Gastroenterological Association
  • Member, The American Society for Clinical Investigation (ASCI)
  • Member, Society for Developmental Biology (SDB)
  • Editor-in-Chief Journal of Respiratory Biology and Translational Medicine
  • Review Editor, Frontiers in Cell and Developmental Biology

Honors & Awards

2024 Elected Member of The Association of American Physicians
2023 Irene and Arthur Fishberg Price (2023), Columbia University
2022 CALA (Chinese-American Lung Association) Established Investigator Award
2018 Elected Member of The American Society for Clinical Investigation
2014 NYSTEM IDEA Award, New York State Stem Cell Foundation
2012 Basil O’Connor Research Scholar Award, March of Dimes Research Foundation
2010 NIH Pathway to Independence Award (K99/R00), NIDDK

Research

The Que Laboratory focuses on the development, stem cell biology and disease of foregut-derived organs, including the esophagus, stomach, and lung. Dr. Que’s lab has developed a series of mouse models combined with iPSC modeling to investigate the generation and regeneration of epithelial cells in the esophagus and lung. His research also explores diseases affecting these organs, such as pulmonary fibrosis, COVID-19 sequelae, eosinophilic esophagitis, and Barrett’s esophagus. Dr. Que’s work extends to cancer research in the esophagus, stomach, and lung. His lab has demonstrated the role of neurons in the progression of small cell lung carcinoma (SCLC) and identified the involvement of gastric stem cells in gastric cancer progression.

Research Interests:

Lung cancer initiation; Lung development and regeneration; Upper GI cancer initiation and progression; Esophageal stem cell in maintenance and disease; Gastric stem cells in tissue maintenance and disease.

Selected Publications

  1. Fang Y, Chung SSW, Xu L, Xue C, Liu X, Jiang D, Li R, Korogi Y, Yuan K, Saqi A, Hibshoosh H, Huang Y, Lin CS, Tsukui T, Sheppard D, Sun X*, Que J*. RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. 2025 Feb 5. doi: 10.1038/s41586-024-08542-2. Online ahead of print. PMID: 39910313 *Co-corresponding author.
  2. Fnu T, Shi P, Zhang W, Chung SSW, Damoci CB, Fang Y, Chen QY, Saqi A, Huang Y, Wu X, Lu C, Yang D, Wang TC, Que J. Sympathetic Neurons Promote Small Cell Lung Cancer Through the Beta-2 Adrenergic Receptor. Cancer Discovery. 2024 Nov 8. doi: 10.1158/2159-8290.CD-24-0718. Online ahead of print. PMID: 39513738
  3. Chen Q, Weng K, Lin M, Jiang M, Fang Y, Chung SSW, Huang X, Zhong Q, Liu Z, Huang Z, Lin J, Li P, El-Rifai W, Zaika A, Li H, Rustgi AK, Nakagawa H, Abrams JA, Wang TC, Lu C, Huang C, Que J. SOX9 Modulates the Transformation of Gastric Stem Cells Through Biased Symmetric Cell Division. Gastroenterology. 2023 Feb 4:S0016-5085(23)00109-9. doi: 10.1053/j.gastro.2023.01.037. Online ahead of print. PMID: 36740200
  4. Melms JC, Biermann J, Huang H, Wang Y, Nair A, Tagore S, Katsyv I, Rendeiro AF, Amin AD, Schapiro D, Frangieh CJ, Luoma AM, Filliol A, Fang Y, Ravichandran H, Clausi MG, Alba GA, Rogava M, Chen SW, Ho P, Montoro DT, Kornberg AE, Han AS, Bakhoum MF, Anandasabapathy N, Suárez-Fariñas M, Bakhoum SF, Bram Y, Borczuk A, Guo XV, Lefkowitch JH, Marboe C, Lagana SM, Del Portillo A, Tsai EJ, Zorn E, Markowitz GS, Schwabe RF, Schwartz RE, Elemento O, Saqi A, Hibshoosh H, Que J*, Izar B*. A molecular single-cell lung atlas of lethal COVID-19. Nature. 2021 Jul;595(7865):114-119. doi: 10.1038/s41586-021-03569-1. Epub 2021 Apr 29. PMID: 33915568. *Co-corresponding author.

For a complete list of publications, please visit PubMed.gov