Courses

Course Director: Nihkil Sharma

Course Director: Nihkil Sharma

Course Director: Nihkil Sharma

This spring semester course provides an introduction to the basic statistics commonly used in biomedical research laboratories. Students are provided with a statistical software package for use during the course. Exercises based on relevant experimental data sets use the software to reinforce the lecture material. Topics covered include the role of statistics in biomedical research, principles of statistical analysis, and selecting and applying the appropriate statistical tests. Course Directors: Arthur Palmer.

Course Director: Nihkil Sharma

This fall-semester course is required for all first-year students and covers basic biochemical and experimental principles, such as protein and nucleic acid structure and chemistry, thermodynamics and enzyme kinetics, and bioinformatics. Also included are biochemical processes common to all cells, such as genome replication and repair, regulation of gene expression, cell-cycle control, and cell membrane and receptor biochemistry. Course Directors: Anna-Lena Steckelberg and Hashim Al-Hashimi.

This course provides a detailed analysis of the biophysical and structural properties of ionic channels in biological membranes. In addition, the physiological role of such channels in regulating neuronal excitability is covered. Course Director: Steven Siegelbaum.

This course provides an in-depth analysis of several organ systems and diseases associated with each organ system. The course has four modules; each module describes the basic physiology, nutritional status and anatomy of the organ system, the genetics, cell and biochemical mechanisms and pathologies associated with the disease, as well as basic pharmacology and therapeutics to treat the disease. Course Directors: Ronald Liem and Steven Spitalnik.

Methods and principles involved in studying the structure and function of proteins, nucleic acids, membranes, and their macro-molecular assemblies. Noncovalent forces and conformational analysis; ultracentrifugation, viscometry, circular dichroism, fluorescence, magnetic resonance; conformational changes in proteins and nucleic acids, topological properties of macromolecules. Course Director: Arthur Palmer.

The Course will comprise general lectures, analyses and discussions of primary literature on stem cell and cell lineage specification biology as well as student presentations. The themes to be presented include basic cell and molecular biological characterization of stem cells, regulation of self-replication versus lineage restriction and differentiation of cells, model systems used in studies of stem cells, and the relevance of tissue formation, regeneration and disease states. Course Directors: Stephen Tsang and Dietrich Egli.

This course provides an in-depth introduction to principles of modern sequencing, key computational algorithms and statistical models, and applications in disease genetics, cancer and fundamental biology. It will cover genome, exome, transcriptome, and epigenome sequencing approaches. Emphasis will be placed on understanding the interplay between experimental design, data acquisition, and data analysis so that students can apply these powerful tools in their own research. Course Directors: Yufeng Shen, Peter Sims, and Chaolin Zhang

Basic Unix, website usage, sequence comparison, database searching, multiple sequence alignment, profile methods, secondary structure prediction, mapping, primer design, genomic analysis, and functional genomics, including micro-array analysis. Course Director: Richard Friedman.

Required for C2B2 students in the spring semester, this course will present computational approaches of reconstruction, analysis, and simulation of cellular networks. Metabolic, signaling, and protein-interaction networks will be covered. The networks will be discussed at several levels of structural organization: overall network, functional and structural modules, network motifs. We will emphasize how specific biophysical and biochemical properties of different networks lead to conceptual simplifications for analysis and simulation. Network evolution and similarities between cellular and nonbiological networks will be discussed. Course Director: Dennis Vitkup.

This fall-semester course is required for all first-year students and covers aspects of molecular biology and genetics, from prokaryotes to mammals, including regulation of gene expression, molecular genetics of bacterial viruses, plasmids, and transposable elements, as well as modern molecular genetic approaches to complex biological phenomena. Format: four to five hours of lecture and discussion per week. Course Director: Jonathan Dworkin.

The course emphasizes the molecular control of vertebrate embryogenesis. Divided into three main areas: early embryogenesis, developmental neurobiology, and the development and differentiation of specialized organs or lineages. Course Director: Andrew Tomlinson.

Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problems sets on the current literature. Course Director: Tim Bestor.

This course is designed to illustrate how genetic systems have played a fundamental role in our understanding of basic biological problems. Topics include mitosis and meiosis, chromosomal linkage and mapping, consequences of chromosomal rearrangements, mechanisms of recombination and gene conversion, the use of mutants to study gene structure, regulation and the cell cycle, uses of recombinant DNA in genetic analysis, and the genetic analysis of development in Drosophila.

Survey of the major topics in basic immunology with an emphasis on the molecular basis for immune recognition and regulation. Course Director: Steven Reiner.

Course Director: Steven Reiner

Course Director: Anne Moscona

Course Director: Vincent Ferrera

Course Director: (Wesley Grueber)

An integrated and critical review of cancer biology, emphasizing recent research. Topics discussed include: natural history and epidemiology of cancer; morphology and behavior of cancer cells; DNA and RNA tumor viruses; oncogenes; tumor suppressor genes; signal transduction; the genetics of cancer; cancer and cellular differentiation; cancer causation: physical and chemical agents; multistage carcinogenesis; hormones, nutrients, and growth factors in cancer. Readings are largely original research papers and review articles. One 2-hour seminar per week. Course director: Richard Baer.

Course Director: Harmen Bussemaker